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Updated: May 31, 2026

An Ex vivo Model to Study Hormone Action in the Human Breast
Published on: January 8, 2015
Hormone receptor status in breast cancer and its relation to age and other prognostic factors
Ali Pourzand1, M Bassir A Fakhree, Shahryar Hashemzadeh
1Department of General Surgery, Imam Reza Hospital, Tabriz University of Medical Sciences, Iran.
Background:
Increasing evidence shows the importance of young age, estrogen receptor (ER), progesterone receptor (PR) status, and HER-2 expression in patients with breast cancers.
Patients And Methods:
We organized an analytic cross-sectional study of 105 women diagnosed with breast cancer who have been operated on between 2008 to 2010. We evaluated age, size, hormone receptor status, HER-2 and P53 expression as possible indicator of lymph node involvement.
Results:
There is a direct correlation between positive progesterone receptor status and being younger than 40 (P < 0.05). Also, compared with older women, young women had tumors that were more likely to be large in size and have higher stages (P < 0.05). Furthermore patients with negative progesterone receptor status were more likely to have HER-2 overexpression (P < 0.05). The differences in propensity to lymph node metastasis between hormone receptor statuses were not statically significant.
Conclusions:
Although negative progesterone receptor tumors were more likely to have HER-2 overexpression, it is possible that higher stage and larger size breast cancer in younger women is related to positive progesterone receptor status.
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