Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unmet Need: Mechanistic and Translational Studies of Sickle Cell Disease Pain as a Whole-Person Health Challenge.

The journal of pain·2024
Same author

The National Center for Complementary and Integrative Health: Priorities for Cannabis and Cannabinoid Research.

The Journal of pharmacology and experimental therapeutics·2024
Same author

Post-concussion symptoms and chronic pain after mild traumatic brain injury are modulated by multiple locus effect in the <i>BDNF</i> gene through the expression of antisense: A pilot prospective control study.

Canadian journal of pain = Revue canadienne de la douleur·2022
Same author

Association of Protein and Genetic Biomarkers With Response to Lumbar Epidural Steroid Injections in Subjects With Axial Low Back Pain.

American journal of physical medicine & rehabilitation·2020
Same author

Acupuncture Versus Opioids for Pain Relief: An Expert Discussion.

Medical acupuncture·2020
Same author

AAAPT Diagnostic Criteria for Acute Pain Following Breast Surgery.

The journal of pain·2019

Related Experiment Video

Updated: May 31, 2026

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing
09:16

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing

Published on: February 16, 2017

COMT genetic variants and pain.

Inna Belfer1, S Segall

  • 1Molecular Epidemiology of Pain Program, Department of Anesthesiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. belferi@upmc.edu

Drugs of Today (Barcelona, Spain : 1998)
|June 23, 2011
PubMed
Summary
This summary is machine-generated.

Genetic variations in the Catechol-O-methyltransferase (COMT) enzyme influence human pain perception and response to pain medication. Understanding COMT polymorphisms may help predict pain conditions and patient outcomes.

Related Experiment Videos

Last Updated: May 31, 2026

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing
09:16

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing

Published on: February 16, 2017

Area of Science:

  • Neuroscience
  • Genetics
  • Pharmacology

Background:

  • Catechol-O-methyltransferase (COMT) is crucial for metabolizing key neurotransmitters like dopamine, influencing mood, cognition, and stress.
  • Human pain perception is intricately linked to these neurotransmitter systems.
  • The COMT gene exhibits functional polymorphisms, leading to significant inter-individual differences in pain experiences.

Purpose of the Study:

  • To review pain symptoms and syndromes associated with COMT functional variations.
  • To summarize genetic association study findings related to COMT and pain.
  • To provide a critical outlook on current research regarding COMT's role in pain.

Main Methods:

  • Literature review of pain symptoms and syndromes.
  • Summary of genetic association studies on COMT and pain phenotypes.
  • Critical analysis of existing research findings.

Main Results:

  • COMT functional variations are linked to variability in pain sensitivity, chronicity, and severity.
  • Polymorphisms in the COMT gene affect individual responses to pain medication.
  • Specific pain symptoms and syndromes are demonstrably influenced by COMT activity.

Conclusions:

  • While the precise mechanisms are still under investigation, COMT plays a significant role in human pain.
  • COMT functional variation has the potential to predict clinical pain outcomes.
  • Identifying patients at risk for pain conditions may be enhanced by considering COMT status.