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A Catheter-Related Candida albicans Infection Model in Mouse
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Clinical practice: Obstructive renal candidiasis in infancy.

Veena Bisht1, Judith VanDer Voort

  • 1Department of Paediatric Nephrology, University Hospital of Wales, Cardiff CF14 4XW, UK. veenabisht@hotmail.com

European Journal of Pediatrics
|June 23, 2011
PubMed
Summary
This summary is machine-generated.

Renal candidiasis can cause obstructive uropathy in infants. Prompt diagnosis and varied treatments, including antifungals and surgical intervention, are crucial for preserving kidney function in affected neonates and infants.

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Area of Science:

  • Pediatric Nephrology
  • Neonatology
  • Mycology

Background:

  • Renal candidiasis is an emerging condition in premature and term infants.
  • Risk factors include neonatal intensive care and congenital urogenital anomalies.
  • Obstructive uropathy from fungal balls is a rare but serious complication.

Purpose of the Study:

  • To clarify definitions and identify infants at risk for renal candidiasis obstruction.
  • To review clinical presentation, diagnosis, and imaging modalities.
  • To summarize current literature on treatment options for obstructive renal bezoars.

Main Methods:

  • Literature review of case reports and series on renal candidiasis.
  • Analysis of definitions, risk factors, and clinical presentations.
  • Synthesis of treatment strategies, including antifungal therapy and surgical interventions.

Main Results:

  • Identified key risk factors and clinical signs of obstructive renal candidiasis.
  • Detailed diagnostic approaches and the role of imaging.
  • Outlined diverse treatment options: systemic/local antifungals, fibrinolytic agents, and surgical removal.

Conclusions:

  • Management of obstructive renal bezoars is complex and requires tailored approaches.
  • Clinicians must be aware of multiple treatment options beyond standard antifungal therapy.
  • A proposed simplified algorithm aims to guide management of this challenging diagnosis.