Common and specific sequences in picornaviruses

Enteroviruses and rhinoviruses were studied by nucleic acid hybridization using oligonucleotide probes. The reactivity of these sequences varied from serotype specificity to wide reactivity with nearly all human picornaviruses tested. Widely reactive sequences were from the 5' non-coding region while specific oligonucleotides were found from the coding region. Sequences that were common to both enteroviruses and human rhinoviruses were identified and one of the oligonucleotides reacted with a majority enterovirus serotypes.