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Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

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Increased plasma fructosamine concentrations in laminitic horses.

E J Knowles¹, J M Withers, T S Mair

¹Bell Equine Veterinary Clinic, Mereworth, Maidstone, UK. e.j.knowles@gmail.com

Equine Veterinary Journal

|June 24, 2011

Summary

Plasma fructosamine concentration is higher in laminitic horses, indicating abnormal glucose control. This finding suggests fructosamine may become a useful clinical marker for equine laminitis.

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Area of Science:

Equine medicine
Veterinary endocrinology
Metabolic disease research

Background:

Plasma fructosamine concentration ([fructosamine]) has not been previously investigated as a marker for abnormal glucose homeostasis in horses with laminitis.
Laminitis is a debilitating condition in horses, often associated with metabolic disturbances.

Purpose of the Study:

To compare plasma fructosamine concentration between laminitic and healthy horses.
To explore the relationship between plasma fructosamine levels and markers of insulin resistance in laminitic horses.
To assess the association between plasma fructosamine and clinical outcomes in laminitic horses.

Main Methods:

Plasma fructosamine, fasting serum insulin, and fasting plasma glucose were measured in 30 laminitic horses and 19 control horses.
Clinical data and follow-up information were collected for all laminitic horses.
Statistical analyses were performed to compare groups and identify correlations.

Main Results:

Laminitic horses exhibited significantly higher mean plasma fructosamine concentrations compared to control horses (P<0.001).
Significant correlations were found between plasma fructosamine and glucose, insulin, and insulin resistance proxies (RISQI, MIRG).
While trends were observed, a statistically significant association between plasma fructosamine and negative outcomes was not established.

Conclusions:

Elevated plasma fructosamine in laminitic horses suggests impaired glycemic control.
Plasma fructosamine shows potential as a valuable clinical biomarker for assessing glucose homeostasis in equine laminitis.