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Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
Published on: February 8, 2018
Emerging Tim-3 functions in antimicrobial and tumor immunity
Kaori Sakuishi1, Pushpa Jayaraman, Samuel M Behar
1Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Trends in Immunology
|June 24, 2011
Summary
T cell immunoglobulin-3 (Tim-3) is a negative regulator of T cell responses, impacting autoimmunity and immune cell exhaustion. Its role in tumor and antimicrobial immunity is emerging.
Area of Science:
- Immunology
- Molecular Biology
- Cellular Biology
Background:
- T cell immunoglobulin-3 (Tim-3) marks differentiated T helper type 1 and T cytotoxic type 1 cells.
- Tim-3 interaction with galectin-9 (Gal-9) induces cell death and regulates T cell responses.
- Tim-3 blockade exacerbates autoimmunity and abrogates tolerance in experimental models.
Purpose of the Study:
- To explore the emerging role of Tim-3 in tumor immunity.
- To investigate the function of Tim-3 in antimicrobial immunity.
- To elucidate additional mechanisms of Tim-3-mediated T cell regulation.
Main Methods:
- Review of recent studies on Tim-3 function.
- Analysis of Tim-3's role in T cell exhaustion.
- Investigation of Tim-3's impact on myeloid-derived suppressor cells.
Main Results:
- Tim-3 negatively regulates T cell responses.
- Tim-3 promotes CD8(+) T cell exhaustion.
- Tim-3 induces expansion of myeloid-derived suppressor cells.
- Tim-3/Gal-9 interaction enhances macrophage clearance of pathogens.
Conclusions:
- Tim-3 is a crucial negative regulator in T cell immunity.
- Tim-3 plays a significant role in tumor immunity.
- Tim-3 is important for effective antimicrobial immunity.
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