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Related Experiment Video

Updated: May 31, 2026

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion
09:23

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion

Published on: April 2, 2020

Indirubins decrease glioma invasion by blocking migratory phenotypes in both the tumor and stromal endothelial cell

Shanté P Williams1, Michal O Nowicki, Fang Liu

  • 1Dardinger Laboratory for Neuro-oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University Medical Center and James Comprehensive Cancer Center, Columbus, Ohio 43210, USA.

Cancer Research
|June 24, 2011
PubMed
Summary

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This summary is machine-generated.

Indirubin GSK-3 inhibitors reduce glioma invasion and proliferation by targeting tumor and endothelial cells. These compounds improved survival in mice by blocking tumor angiogenesis and cell migration.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Neoplastic invasion and proliferation involve complex interactions between tumor and endothelial cells.
  • Glycogen synthase kinase-3 (GSK-3) is a key signaling molecule implicated in cancer cell invasion and proliferation.
  • Targeting GSK-3 presents a potential therapeutic strategy for various cancers.

Purpose of the Study:

  • To investigate the efficacy of GSK-3 inhibitors, specifically indirubins, in combating glioma.
  • To elucidate the role of beta-catenin signaling in indirubin-mediated anti-glioma effects.
  • To assess the impact of indirubins on tumor angiogenesis and endothelial cell migration in vivo.

Main Methods:

  • In vitro and in vivo experiments using glioma cells and neurospheres.

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  • Administration of GSK-3 inhibitors (indirubins) to glioma models.
  • Assessment of cell invasion, proliferation, beta-catenin signaling, and tumor angiogenesis.
  • Evaluation of endothelial cell migration and survival rates in glioma-bearing mice.

    • Main Results:

    • Indirubin GSK-3 inhibitors significantly reduced glioma cell and neurosphere invasion.
    • Beta-catenin signaling was identified as a crucial mediator of indirubin's anti-invasive effects.
    • Indirubins improved survival in glioma-bearing mice, accompanied by decreased blood vessel density.
    • Indirubins inhibited endothelial cell migration, suggesting a dual anti-angiogenic and anti-invasive mechanism.

    Conclusions:

    • Indirubin inhibition of GSK-3 offers a novel therapeutic approach for glioma.
    • This strategy targets both tumor cells and the tumor microenvironment, including endothelial cells.
    • GSK-3 inhibitors represent a promising treatment paradigm for cancers involving complex cellular interactions.