Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predicting pain location from resting-state brain fMRI.

bioRxiv : the preprint server for biology·2026
Same author

Human intracranial signal stability tracks anatomical accuracy after electrode reimplantation.

Journal of neural engineering·2026
Same author

Subsets of Single Neurons Predict Ensemble Activity and Memory Choices.

Hippocampus·2026
Same author

Neuromodulation for Restless Legs Syndrome: A Systematic Review and Mechanistic Considerations for Spinal Cord Stimulation.

Sleep & breathing = Schlaf & Atmung·2026
Same author

Rapid homotopic communication between human orbitofrontal subregions.

Current biology : CB·2026
Same author

Chronic Pain Is a Brain Network Disorder.

JAMA neurology·2025
Same journal

Erratum: Yao et al., "Estrogen Regulates Bcl-w and Bim Expression: Role in Protection against β-Amyloid Peptide-Induced Neuronal Death".

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Erratum: L'Episcopo et al., "Plasticity of Subventricular Zone Neuroprogenitors in MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) Mouse Model of Parkinson's Disease Involves Cross Talk between Inflammatory and Wnt/β-Catenin Signaling Pathways: Functional Consequences for Neuroprotection and Repair".

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Representations of subsecond duration-based timing by complex spike synchrony in cerebellar Purkinje neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

The extended language network: Language-responsive brain areas whose contributions to language remain to be discovered.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Cortical and thalamic afferent connectomes distinguish ACC subregions of the macaque brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

The synaptic vesicle priming protein Munc13 mediates evoked somatodendritic dopamine release.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
See all related articles

Related Experiment Video

Updated: May 31, 2026

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
09:01

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

Memory modulates journey-dependent coding in the rat hippocampus.

Janina Ferbinteanu1, Prasad Shirvalkar, Matthew L Shapiro

  • 1Dr. Arthur M. Fishberg Department of Neuroscience, Alfred B. and Gudrun J. Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, New York 10029-6574, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|June 24, 2011
PubMed
Summary
This summary is machine-generated.

Hippocampal place fields encode spatial journeys, with coding strategies changing based on memory demands. This journey-dependent neural activity directly links to memory formation and recall in rats.

More Related Videos

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
13:34

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

Related Experiment Videos

Last Updated: May 31, 2026

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
09:01

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
13:34

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Memory Research

Background:

  • Neurons in the rat hippocampus, known as place cells, form place fields that signal current location.
  • During goal-directed tasks, these place fields can encode past and future positions, a phenomenon termed journey-dependent activity.
  • The precise role of journey-dependent activity in hippocampus-dependent memory remains unclear.

Purpose of the Study:

  • To investigate the relationship between hippocampal journey-dependent activity and memory.
  • To compare neural firing patterns in rats performing a hippocampus-dependent spatial navigation task versus a hippocampus-independent cue response task in a plus maze.

Main Methods:

  • Rats performed two distinct tasks in a plus maze: a spatial navigation task and a cue response task.
  • Neural firing patterns in the hippocampus were recorded and analyzed.
  • Coding strategies (place, prospective, retrospective) were examined before and after the choice point in the maze.

Main Results:

  • Journey-dependent coding reflected temporally extended behavioral episodes in both tasks.
  • Before the choice point, a switch in task elicited a change in a place field's coding category, indicating adaptive coding based on memory strategy.
  • After the choice point, place fields maintained their coding categories across tasks, suggesting preserved memory encoding.
  • Firing rates on the goal arm predominantly encoded journey, while firing rates on the start arm were influenced by both task and journey.

Conclusions:

  • Hippocampal journey-dependent coding is directly linked to memory.
  • Neural episodes are encoded through both population activity and firing rate coding within the hippocampus.
  • The hippocampus dynamically adjusts its neural coding strategies based on mnemonic demands and task progression.