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Related Experiment Video

Updated: May 31, 2026

Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
05:44

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Published on: July 14, 2016

Anti-saccade performance predicts executive function and brain structure in normal elders.

Jacob B Mirsky1, Hilary W Heuer, Aria Jafari

  • 1Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94143, USA.

Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology
|June 24, 2011
PubMed
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The anti-saccade (AS) task effectively identifies executive dysfunction in normal elders. Performance on this task correlates with brain structure, suggesting its utility in assessing age-related cognitive changes.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Gerontology

Background:

  • The anti-saccade (AS) task is linked to executive function and frontal lobe volume in neurological conditions.
  • Its utility in well-characterized normal elderly populations remains understudied.
  • Executive dysfunction in elders may predict cognitive decline.

Purpose of the Study:

  • To investigate the neuropsychological and anatomical underpinnings of anti-saccade (AS) task performance in healthy older adults.
  • To determine if AS task performance is sensitive to age-related cognitive changes.

Main Methods:

  • Assessed percentage of correct AS responses in 48 normal elderly subjects.
  • Utilized linear regression to associate AS performance with neuropsychological tests.

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  • Employed voxel-based morphometry on MRI scans to analyze gray matter volume.

    • Main Results:

    • Correct AS responses correlated with executive function measures (e.g., modified trails, Stroop inhibition).
    • AS performance was associated with gray matter volume in the left inferior frontal junction and right supplementary eye field.
    • The link between AS performance and executive function was more pronounced in individuals with less education.

    Conclusions:

    • The anti-saccade (AS) task is a sensitive indicator of executive dysfunction in normal aging.
    • AS task performance reflects structural changes in frontal brain regions associated with inhibitory control.