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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Biomarkers in chronic kidney disease: a review

Robert G Fassett1, Sree K Venuthurupalli, Glenda C Gobe

  • 1Renal Research, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia. r.fassett@uq.edu.au

Kidney International
|June 24, 2011
PubMed

Insights

New biomarkers show promise for identifying chronic kidney disease (CKD) progression and cardiovascular disease (CVD) risk. Further research is needed to validate these sensitive markers for clinical use.

Area of Science:

  • Nephrology
  • Biomarker Discovery
  • Cardiovascular Disease

Background:

  • Chronic kidney disease (CKD) is a significant global health issue.
  • Current methods like eGFR and proteinuria have limitations in predicting CKD progression and associated cardiovascular disease (CVD).
  • There is a need for more sensitive biomarkers for early identification of high-risk patients.

Purpose of the Study:

  • To review recently identified biomarkers for predicting CKD progression and CVD risk.
  • To discuss the potential of novel biomarkers in understanding kidney function and cardiovascular risk.
  • To highlight the need for validation of these biomarkers in diverse populations.

Main Methods:

  • Review of recent scientific literature on novel renal biomarkers.
  • Analysis of candidate biomarkers such as neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, and liver-type fatty acid-binding protein.
  • Discussion on the role of multi-biomarker panels for personalized CKD management.

Main Results:

  • Several promising biomarkers have been identified for CKD progression and CVD risk.
  • These novel biomarkers may offer greater sensitivity in assessing kidney function and cardiovascular risk.
  • Current biomarkers have limitations, necessitating the exploration of new markers.

Conclusions:

  • Novel biomarkers like NGAL, KIM-1, and L-FABP show potential for predicting CKD progression and CVD risk.
  • A panel of biomarkers, including disease-specific ones, may be required due to the diverse causes of CKD.
  • Large-scale longitudinal studies are essential to validate these biomarkers before clinical implementation.

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