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Updated: May 31, 2026

Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry
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Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry

Published on: November 22, 2024

Liquid phase ion mobility spectrometry.

Maggie Tam1, Herbert H Hill

  • 1Department of Chemistry, Washington State University, Pullman, WA 99164, USA.

The Analyst
|June 24, 2011
PubMed
Summary
This summary is machine-generated.

A new technique, Liquid Phase Ion Mobility Spectrometry (LiPIMS), uses Electrodispersion Ionization to analyze aqueous analytes in non-aqueous solvents. This method shows potential as a novel separation technique for various compounds.

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Area of Science:

  • Analytical Chemistry
  • Separation Science
  • Spectrometry

Background:

  • Traditional analytical methods face challenges in analyzing aqueous analytes in non-aqueous environments.
  • Development of novel ionization and separation techniques is crucial for advancing chemical analysis.

Purpose of the Study:

  • To demonstrate a novel analytical method, Liquid Phase Ion Mobility Spectrometry (LiPIMS).
  • To introduce and characterize Electrodispersion Ionization as a liquid-phase ionization source.
  • To present the potential of LiPIMS as a new separation technique.

Main Methods:

  • Demonstration of LiPIMS involving ionization of aqueous analytes and their transport in non-aqueous liquids via an electric field.
  • Utilizing Electrodispersion Ionization for ion generation from aqueous samples in solvents like hexane and benzene.
  • Controlling ionization parameters (voltage, flow rate) for continuous and pulsed ionization modes.

Main Results:

  • Successful generation of nanoampere ion currents in non-aqueous solvents using Electrodispersion Ionization.
  • Acquisition of unique LiPIMS spectra for aqueous samples including tetramethylammonium bromide, tetrabutylammonium bromide, and bradykinin.
  • Determination of liquid-phase ion mobility values for the tested analytes.

Conclusions:

  • LiPIMS is a viable novel analytical method for analyzing aqueous analytes in non-aqueous solutions.
  • Electrodispersion Ionization is an effective liquid-phase ionization technique suitable for LiPIMS.
  • LiPIMS demonstrates potential as a new separation technique with determined ion mobility values.