[Daily variations in the secretion of several hormones in obesity]

The 24-hour variations in the corticotropine, cortizol, thyrotropin, thyroxin, renin, aldosterone, and somatotropin secretion were studied in patients with obesity with the excess of body weight of 51--133% (84.7 + 7.8%) and in healthy persons of normal weight. Obesity proved to be accompanied by marked disturbances of the 24-hour variations of corticotropine, cortizol, thyrotropin, thyroxin, renin, and aldosterone. Unequally marked shifts in 24-hour variations in the secretion of various hormones indicated different changes in the corresponding structures of the hypothalamus during the obesity development. Changes in 24-hour variations in corticotropine and cortizol secretion were in the same direction in alimentary-constitutional and hypothalamic obesity.