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Incidence of intussusception in early infancy: a capture-recapture estimate for Germany

S Weiß1, A Streng, R von Kries

  • 1Ludwig-Maximilians-Universität München, Institute for Social Paediatrics and Adolescent Medicine, Germany. susanne.weiss@med.uni-muenchen.de

Klinische Padiatrie
|June 24, 2011
PubMed

Insights

Rotavirus vaccination requires careful monitoring for intussusception (IS). This study found that IS incidence in infants under one year varies significantly by age, crucial for evaluating new rotavirus vaccines.

Area of Science:

  • Pediatric epidemiology
  • Vaccine safety surveillance
  • Gastroenterology

Background:

  • First-generation rotavirus (RV) vaccines were linked to intussusception (IS).
  • Accurate baseline incidence data for infants under six months is vital for monitoring new RV vaccines.
  • Understanding age-specific IS rates is crucial for post-marketing surveillance.

Purpose of the Study:

  • To estimate the age-specific incidence of intussusception (IS) in infants under one year in Germany.
  • To provide reliable baseline data for monitoring the safety of new rotavirus vaccines.

Main Methods:

  • A two-source capture-recapture calculation (CRC) was used.
  • Data was sourced from the German Paediatric Surveillance Unit (ESPED) and hospital discharge records.
  • Cases were validated using the Brighton Collaboration's definition for definite IS.

Main Results:

  • The annual IS incidence in German infants (<1 year) was estimated at 61.7/100,000.
  • Incidence varied by age, ranging from 19.2/100,000 in the first three months to 98.5/100,000 between months six and eight.
  • The male to female ratio for infant IS was 1.7:1.

Conclusions:

  • The overall IS incidence estimate in infants aligns with previous studies in Germany and Switzerland.
  • Age-specific baseline incidence of IS shows significant variation within the first year of life.
  • These age-specific variations must be considered when assessing potential links between IS and rotavirus vaccination.
Abstract

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