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Related Experiment Video

Updated: May 31, 2026

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Published on: November 17, 2018

Metronidazole and the immune system.

L Shakir¹, A Javeed, M Ashraf

¹Department of Pharmacology & Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan.

|June 25, 2011

Summary

Metronidazole (MTZ), an antibiotic, also impacts the immune system. This review details its effects on innate and acquired immunity, inflammation, and immune responses like DTH and GVHD.

Area of Science:

Immunology
Pharmacology
Microbiology

Background:

Metronidazole (MTZ) is a nitroimidazole antibiotic primarily used for anaerobic bacterial and protozoal infections.
Beyond its antimicrobial and antiprotozoal actions, MTZ exhibits significant immunopharmacological properties.

Purpose of the Study:

To review the multifaceted effects of Metronidazole on various components of the immune system.
To highlight the immunopharmacological relevance of MTZ in inflammatory conditions, delayed type hypersensitivity (DTH), and graft versus host disease (GVHD).

Main Methods:

Literature review of studies investigating Metronidazole's impact on immune functions.
Analysis of research focusing on MTZ's role in innate and acquired immunity.
Examination of MTZ's influence on inflammatory processes and specific immune responses.

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Last Updated: May 31, 2026

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Published on: November 17, 2018

Measuring Granulocyte and Monocyte Phagocytosis and Oxidative Burst Activity in Human Blood

Measuring Granulocyte and Monocyte Phagocytosis and Oxidative Burst Activity in Human Blood

Published on: September 12, 2016

Main Results:

Metronidazole modulates both innate and acquired immune responses.
MTZ influences key aspects of inflammation.
The drug's immunopharmacological actions are relevant to DTH and GVHD.

Conclusions:

Metronidazole possesses significant immunomodulatory effects beyond its antimicrobial activity.
Understanding MTZ's immunopharmacology is crucial for its clinical application in immune-related conditions.
Further research into MTZ's immune interactions may reveal novel therapeutic strategies.