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Author Spotlight: Enhancing Lipid Nanoparticle Formation Through Turbulent Mixing in Confined Geometries
Published on: August 23, 2024
[Na-pump regulation by liponucleotides:its mechanism and physiological significance]
Abstract:
A short-term regulation of Na,K-ATPase by the long-chain fatty acid esters and coenzyme A (liponucleotides) has been studied. It has been found that in the presence of liponucleotides the maximum velocity of ATP-hydrolysis doesn't change, but the apparent KM value decreases. While studying the ion transport it has been shown that palmitoyl-CoA stimulates the pump approaching the cell membrane from the cytoplasmic side, being an intracellular regulator of Na,K-ATPase. A possible mechanism of liponucleotide action on the process of enzyme functioning and its physiological implications is discussed.
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