Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Time-dependent cytokine landscapes in an ex vivo microfluidic glioblastoma platform.

Cancer immunology, immunotherapy : CII·2026

Same author

Antibody format matters: A comparative analysis of VHH and scFv domains reveals superior in vivo CAR T cell function with VHH domains.

Molecular therapy : the journal of the American Society of Gene Therapy·2026

Same author

The costs and benefits of an early access scheme for oncology medicines in Ireland.

BMC health services research·2026

Same author

Experiences of racially, ethnically, sexual- and gender-minoritized adolescents and young adults with cancer in the Canadian health care system.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026

Same author

How can we prevent clinical deskilling when using AI?

BMJ quality & safety·2026

Same author

Editorial: Optimizing medication management in older adults: addressing polypharmacy, deprescribing and represcribing challenges.

Frontiers in medicine·2026

Search research articles

Related Experiment Video

Updated: May 31, 2026

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

Radiotherapy for atypical meningiomas.

Richard Mair¹, Kevin Morris, Ian Scott

¹Department of Neurosurgery, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield, USA.

Journal of Neurosurgery

|June 25, 2011

Summary

Postoperative radiotherapy is not recommended after gross-total resection of WHO Grade II meningiomas. Radiosurgery is advised for residual tumor, with radiotherapy reserved for large remnants unsuitable for radiosurgery.

More Related Videos

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Published on: October 27, 2014

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

Published on: April 16, 2019

Related Experiment Videos

Last Updated: May 31, 2026

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma

Published on: October 27, 2014

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

Published on: April 16, 2019

Area of Science:

Neurosurgery
Radiation Oncology
Oncology

Background:

The role of postoperative radiotherapy for WHO Grade II meningiomas is debated.
Existing literature often uses outdated WHO grading criteria.

Purpose of the Study:

To investigate the efficacy of postoperative radiotherapy in patients with WHO Grade II meningiomas using current diagnostic criteria.
To clarify treatment guidelines for atypical meningiomas after initial surgical resection.

Main Methods:

Retrospective analysis of 114 patients with WHO Grade II meningiomas diagnosed using 2000 WHO criteria.
Evaluation of outcomes, including radiological recurrence, using Kaplan-Meier and Cox regression analyses.
Varied use of postoperative radiotherapy based on surgeon preference.

Main Results:

Postoperative radiotherapy showed benefit only when gross-total resections and subtotal resections with radiosurgery were excluded.
This suggests radiotherapy's benefit is limited in specific resection scenarios.

Conclusions:

Radiotherapy is not indicated after gross-total resection (Simpson Grade 1 or 2) of WHO Grade II meningiomas.
Radiosurgery is recommended for residual tumor after initial resection.
Postoperative radiotherapy should be reserved for unresectable remnants where radiosurgery is not feasible.