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A primary defect in glucose production alone cannot induce glucose intolerance without defects in insulin secretion

Salvatore P Mangiafico1, Shueh H Lim, Sandra Neoh

  • 1Department of Medicine, Heidelberg Repatriation Hospital, University of Melbourne, 300 Waterdale Road, Heidelberg Heights, Melbourne, Victoria 3081, Australia.

The Journal of Endocrinology
|June 25, 2011
PubMed
Summary

A primary defect in glucose production alone does not cause glucose intolerance. Insulin resistance and impaired insulin secretion are necessary to precipitate glucose intolerance, even with elevated gluconeogenesis (GNG).

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