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Related Concept Videos

Olfaction01:25

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...

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Related Experiment Video

Updated: May 31, 2026

Olfactory Context Dependent Memory: Direct Presentation of Odorants
04:47

Olfactory Context Dependent Memory: Direct Presentation of Odorants

Published on: September 18, 2018

ODORactor: a web server for deciphering olfactory coding.

Xinyi Liu1, Xubo Su, Fei Wang

  • 1Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, 200025, China.

Bioinformatics (Oxford, England)
|June 25, 2011
PubMed
Summary
This summary is machine-generated.

ODORactor is a new web server that identifies odorant receptors (ORs) for chemicals. This tool aids in understanding olfactory coding and discovering new odorants.

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Published on: September 18, 2018

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09:53

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase

Published on: April 23, 2019

Area of Science:

  • * Computational chemistry
  • * Bioinformatics
  • * Chemoinformatics

Background:

  • * Identifying odorant receptors (ORs) for small molecules is crucial for understanding olfaction.
  • * Existing tools lack comprehensive functionalities for OR prediction and ligand pair browsing.
  • * Manual curation of olfactory information from literature is time-consuming.

Purpose of the Study:

  • * To develop ODORactor, an open-access web server for identifying ORs and browsing OR-ligand pairs.
  • * To enable prediction of ORs from chemical structures by integrating odorant verification and OR recognition.
  • * To provide a curated database of olfactory information.

Main Methods:

  • * Integration of odorant verification and OR recognition algorithms.
  • * Development of a web server interface for user interaction.
  • * Experimental validation of predicted OR-ligand pairs.
  • * Manual curation of olfactory data from scientific literature.

Main Results:

  • * ODORactor successfully predicts odorant receptors for small molecules.
  • * Predictions were experimentally validated for several odorants.
  • * The server provides a comprehensive, manually curated database of olfactory information.
  • * ODORactor integrates functionalities for both OR prediction and browsing existing OR-ligand pairs.

Conclusions:

  • * ODORactor serves as a valuable platform for identifying odorant receptors and their ligands.
  • * The tool facilitates deciphering olfactory coding.
  • * ODORactor is a useful resource for academic olfaction research and industrial odorant discovery.