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Related Experiment Video

Updated: May 31, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Does ventricular dyssynchrony on echocardiography predict response to cardiac resynchronisation therapy? A randomised

Ihab G Diab1, Ross J Hunter, Ravindu Kamdar

  • 1Cardiology Research Department, Barts and The London NHS Trust and Queen Mary University of London, St Bartholomew’s Hospital, London, UK.

Heart (British Cardiac Society)
|June 25, 2011
PubMed
Summary

Echocardiography identifies patients most likely to benefit from cardiac resynchronisation therapy (CRT). Even without echocardiographic dyssynchrony, CRT offers benefits and avoids deterioration, supporting its use in selected heart failure patients.

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Last Updated: May 31, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Published on: April 11, 2025

Area of Science:

  • Cardiology
  • Medical Imaging
  • Heart Failure Management

Background:

  • Cardiac resynchronisation therapy (CRT) is a treatment for heart failure.
  • Predicting CRT response is crucial for patient selection.
  • Echocardiography can assess mechanical dyssynchrony.

Purpose of the Study:

  • To evaluate the predictive value of echocardiography for CRT response.
  • To compare outcomes in heart failure patients with and without echocardiographic dyssynchrony undergoing CRT.

Main Methods:

  • Prospective randomized study of 73 heart failure patients (NYHA III-IV, QRS ≥120 ms, LVEF <35%).
  • Group 1: CRT-D with echocardiographic dyssynchrony. Group 2: No dyssynchrony, randomized to CRT-D (2a) or ICD (2b).
  • Outcomes measured: peak oxygen consumption (VO2max), NYHA class, echocardiography at baseline and 6 months.

Main Results:

  • 62% of Group 1 (with dyssynchrony) improved VO2max with CRT-D vs. 50% in Group 2a (no dyssynchrony, CRT-D) and 21% in Group 2b (no dyssynchrony, ICD).
  • Group 1 showed significant improvements in VO2max, NYHA class, and LVEF with CRT-D.
  • Group 2a showed NYHA class improvement but no change in LVEF or VO2max with CRT-D; Group 2b showed no improvement and VO2max decline.

Conclusions:

  • Echocardiographic dyssynchrony identifies heart failure patients with the greatest CRT benefit.
  • Patients without echocardiographic dyssynchrony still benefit from CRT and experience less deterioration compared to ICD alone.
  • CRT should be considered for patients without echocardiographic dyssynchrony who meet other criteria.