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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Human CD8-iTreg are potent GVHD suppressors and tumoricidal effectors by release of Granzyme-K <sup>+</sup> Supramolecular Attack Particles.

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Related Experiment Video

Updated: May 31, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Prostate cancer immunotherapy.

Kenneth F May1, James L Gulley, Charles G Drake

  • 1Department of Medical Oncology and Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA 02215, USA. kmay1@partners.org

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|June 25, 2011
PubMed
Summary
This summary is machine-generated.

Recent approvals of prostate cancer immunotherapies like sipuleucel-T highlight therapeutic vaccination and immune checkpoint blockade. Further research into immune responses and biomarkers will guide future combination treatments.

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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
11:02

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

Area of Science:

  • Oncology
  • Immunology
  • Urology

Background:

  • Prostate cancer research has long explored immune system interactions.
  • Recent FDA approvals of sipuleucel-T and ipilimumab have boosted interest in cancer immunotherapy.
  • Immunotherapy strategies are increasingly vital in prostate cancer treatment.

Purpose of the Study:

  • To review current immunotherapy strategies for prostate cancer.
  • To discuss the role of therapeutic vaccination and immune checkpoint blockade.
  • To emphasize the need for understanding immune responses and biomarkers.

Main Methods:

  • Review of recent advancements in prostate cancer immunotherapy.
  • Analysis of therapeutic vaccination strategies (e.g., sipuleucel-T, PROSTVAC-VF).
  • Examination of immune checkpoint blockade (CTLA-4, PD-1).

Main Results:

  • Sipuleucel-T and ipilimumab represent significant proof-of-concept immunotherapies.
  • Therapeutic vaccination and immune checkpoint blockade are key strategies.
  • Understanding immune responses is crucial for treatment efficacy.

Conclusions:

  • Further research into immune responses is essential for optimizing immunotherapy.
  • Development of predictive biomarkers will aid patient selection.
  • This knowledge will inform rational combination therapies and future treatments.