Related Experiment Video

Updated: May 31, 2026

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
05:47

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

All-cause mortality in hemodialysis patients with heart valve calcification

Paolo Raggi1, Antonio Bellasi, Christopher Gamboa

  • 11365 Clifton Road NE, Suite AT-504, Atlanta, GA 30322, USA. praggi@emory.edu

Clinical Journal of the American Society of Nephrology : CJASN
|June 25, 2011
PubMed

Insights

Valvular calcification (VC) is common in dialysis patients (CKD-5D) and linked to higher mortality. Mitral valve calcification independently predicts death, highlighting echocardiography

Area of Science:

  • Nephrology
  • Cardiology
  • Radiology

Background:

  • Valvular calcification (VC) is prevalent in patients with chronic kidney disease (CKD-5D).
  • The prognostic impact of VC in CKD patients remains incompletely understood.

Purpose of the Study:

  • To investigate the association between valvular calcification (VC) and all-cause mortality in dialysis patients (CKD-5D).
  • To evaluate the prognostic significance of mitral and aortic valve calcification.

Main Methods:

  • 144 adult CKD-5D patients underwent echocardiography and cardiac CT.
  • Echocardiography assessed qualitative VC; CT quantified coronary artery calcium (CAC) and VC.
  • Patients were followed for a median of 5.6 years for mortality.

Main Results:

  • 38.2% had mitral VC and 44.4% had aortic VC.
  • Mitral VC independently predicted all-cause mortality (HR, 1.73).
  • Calcification in both valves increased mortality risk (HR, 2.16); combined VC and CAC scores strongly correlated with mortality.

Conclusions:

  • Valvular calcification significantly increases all-cause mortality risk in CKD-5D patients.
  • Echocardiography can aid risk stratification in CKD-5D patients, aligning with current guidelines.
Abstract

More Related Videos

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Related Concept Videos

Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this measurement...
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
Mitral Stenosis IV: Nursing Management01:27

Mitral Stenosis IV: Nursing Management

A comprehensive nursing assessment is essential for patients with valvular heart disease, which involves any dysfunction of the heart valves that could impact blood flow and overall heart function.Subjective Data Collection:Chief Complaint and Present Illness: Start with the patient's primary concerns, focusing on the onset, duration, and progression of cardiac symptoms such as dyspnea, fatigue, chest pain, and palpitations.Past Medical History: Collect detailed information on any previous...
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...