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Establishment of a Modified Ferric Chloride-Induced Superior Sagittal Sinus Thrombosis
Published on: December 30, 2025
Superficial siderosis of the CNS
Francisco Rivas Rodriguez1, Ashok Srinivasan
1Department of Radiology, University of Michigan, Alfred Taubman Health Care Center, Ann Arbor, 48109-5030, USA. frivasro@med.umich.edu
Objective:
The objective of this article is to illustrate and describe the cause, physiopathology, natural history, and clinical and imaging presentations of superficial siderosis as a cause of progressive cerebellar ataxia with sensorineural hearing loss and to discuss the therapeutic rationale.
Conclusion:
Superficial siderosis resulting in subpial deposition of hemosiderin along the surface of the cerebellum, brain, spinal cord, and cranial and peripheral nerves is a known cause of progressive cerebellar ataxia and sensorineural hearing loss. MRI evaluation of the entire neuraxis plays a key role in establishing the diagnosis and identifying the source of chronic bleeding. Treatment of the source of bleeding can halt the otherwise deteriorating clinical course of disease.
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