The effect of an NADPH-regenerating system on biphenyl metabolism in isolated rat hepatocytes
Biochimica Et Biophysica Acta
|November 7, 1977
Abstract:
Biphenyl 4-hydroxylation was studied in isolated rat hepatocytes. It was found that there was in inter-relationship between 4-hydroxylase activity and glucuronidase activity, removal of 4-hydroxybiphenyl by conjugation being necessary to stimulate a second phase of hydroxylation. Addition of an NADPH-regenerating system resulted in an initial depression of both processes, but later their activities were enhanced. This action could not be explained by the presence of non-viable cells.
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