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Fluvastatin increases bone mineral density in postmenopausal women
Mituhiro Gotoh1, Kenji Mizuno, Yoshiaki Ono
1Department of Internal Medicine, Fukushima Rosai Hospital, Iwaki, Japan. mgotoh@r2.dion.ne.jp
Fukushima Journal of Medical Science
|June 25, 2011
Summary
Fluzastin treatment in postmenopausal women with high cholesterol significantly increased bone mineral density (BMD) over three years. This suggests statins may positively impact bone health and formation in this demographic.
Area of Science:
- Endocrinology
- Bone Metabolism
- Pharmacology
Background:
- Observational studies suggest statin use correlates with reduced osteoporotic fracture risk.
- Longitudinal data on statin effects on bone mineral density (BMD) and turnover are limited.
Purpose of the Study:
- To investigate the 3-year effects of fluvastatin on BMD and bone turnover in postmenopausal women with hypercholesterolemia.
Main Methods:
- A 3-year prospective study involving 28 postmenopausal hypercholesterolemic women treated with fluvastatin (30 mg/day).
- A control group of 28 age- and BMI-matched postmenopausal women with normal cholesterol levels.
- Bone mineral density (BMD) was assessed at baseline and at 6, 12, 24, and 36 months.
Main Results:
- Fluzastin treatment led to a significant increase in BMD from 6 months onwards (p < 0.001).
- Significant differences in BMD were observed between the fluvastatin and control groups at 6, 12, 24, and 36 months (p < 0.001).
Conclusions:
- Fluzastin treatment appears to have a favorable effect on bone formation and BMD in postmenopausal hypercholesterolemic women.
- Despite the small sample size, the findings suggest a potential benefit of fluvastatin for bone health.
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