Related Experiment Video

Updated: May 31, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

[Current status and future direction of Japan's clinical trial for malignant pleural mesothelioma]

Seiki Hasegawa1, Fumihiro Tanaka, Morihito Okada

  • 1Department of Thoracic Surgery, Hyogo College of Medicine, Mukogawa-cho, Nishinomiya, Japan. hasegawa@hyo-med.ac.jp

Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
|June 25, 2011
PubMed

Insights

This study evaluated trimodality therapy for malignant pleural mesothelioma (MPM) in Japan. It assessed the feasibility of chemotherapy, surgery, and radiation, aiming to provide crucial clinical evidence for Asian populations.

Area of Science:

  • Oncology
  • Thoracic Surgery
  • Clinical Trials

Background:

  • Malignant pleural mesothelioma (MPM) treatment efficacy is debated due to limited clinical evidence.
  • Previous trimodality therapy trials were conducted in Western populations, raising questions about applicability to Asian patients.

Purpose of the Study:

  • To evaluate the feasibility of trimodality therapy for resectable MPM in Japan.
  • To assess the macroscopic complete resection rate and treatment-related mortality of this approach.

Main Methods:

  • A prospective, multi-institutional study was conducted.
  • Patients received induction chemotherapy (pemetrexed plus cisplatin) followed by extrapleural pneumonectomy (EPP) and hemithoracic radiation.
  • Enrollment occurred from May 2008 to November 2010.

Main Results:

  • The study focused on feasibility and safety endpoints.
  • Primary endpoints included macroscopic complete resection rate and treatment-related mortality.

Conclusions:

  • This study provides essential feasibility data for trimodality therapy in an Asian MPM patient cohort.
  • Results contribute to the limited clinical evidence base for MPM treatment strategies.

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