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Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Personality Disorders: Dependent and Obsessive-Compulsive01:24

Personality Disorders: Dependent and Obsessive-Compulsive

Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
 Dependent Personality Disorder
Dependent personality disorder is characterized by an excessive reliance on others to manage various aspects of life. Individuals with this disorder often struggle with...

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Related Experiment Video

Updated: May 31, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Functional neuroimaging in obsessive-compulsive disorder.

A Del Casale1, G D Kotzalidis, C Rapinesi

  • 1NESMOS (Neurosciences, Mental Health, and Sensory Organs) Department, School of Medicine and Psychology, Sapienza University and Sant'Andrea Hospital, Rome, Italy. antonio.delcasale@uniroma1.it

Neuropsychobiology
|June 25, 2011
PubMed
Summary
This summary is machine-generated.

Functional neuroimaging reveals disrupted corticostriatothalamocortical circuitry in obsessive-compulsive disorder (OCD). This dysfunction explains intrusive thoughts and anxiety, linking brain activity to cognitive deficits in OCD patients.

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Last Updated: May 31, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
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Published on: March 14, 2025

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

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Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)
06:26

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)

Published on: November 27, 2019

Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Obsessive-compulsive disorder (OCD) is a prevalent, disabling psychiatric condition often starting in childhood or adolescence.
  • The corticostriatothalamocortical circuitry is implicated in OCD pathogenesis.

Purpose of the Study:

  • To review functional neuroimaging literature in OCD.
  • To analyze dysfunctional connectivity within the corticostriatothalamocortical circuitry.

Main Methods:

  • Literature review of peer-reviewed functional imaging studies in OCD.

Main Results:

  • Striatal dysfunction, particularly the caudate nucleus, impairs thalamic gating.
  • Hyperactivity in the orbitofrontal cortex (intrusive thoughts) and anterior cingulate cortex (anxiety) is observed.
  • Compulsions may serve to manage intrusive thoughts and anxiety via striatal recruitment.
  • Observed cognitive deficits (visuospatial, executive function, motor speed) align with neuroimaging findings.

Conclusions:

  • Functional neuroimaging confirms dysfunctional connectivity in the corticostriatothalamocortical circuitry in OCD.
  • Enhanced neuroimaging resolution may improve understanding of OCD and anxiety disorder neurocircuitry.