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Updated: May 31, 2026
04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Hashimoto's ophthalmopathy.
Fuyuki Tateno1, Ryuji Sakakibara, Masahiko Kishi
1Division of Neurology, Department of Internal Medicine, Sakura Medical Center, Toho University, Sakura, Japan. f-tateno@sakura.med.toho-u.ac.jp
The American Journal of the Medical Sciences
|June 25, 2011
Summary
This study presents two cases of Hashimoto's ophthalmopathy, an autoimmune thyroid eye disease. Early steroid treatment significantly improved symptoms in these patients with atypical presentations.
Area of Science:
- Endocrinology
- Ophthalmology
- Autoimmune Diseases
Background:
- Hashimoto's ophthalmopathy is an autoimmune condition affecting the eyes, often associated with thyroid dysfunction.
- Typical presentations involve proptosis, diplopia, and eyelid retraction.
Observation:
- Two cases of Hashimoto's ophthalmopathy were reported with atypical, acute onset of ophthalmoplegia.
- These cases occurred in euthyroid patients without preceding illness and showed a preference for lateral rectus muscle involvement.
Findings:
- Patients presented with positive antithyroglobulin and antithyroid peroxidase antibodies.
- Both cases demonstrated significant improvement following steroid treatment, indicating a positive response to glucocorticoids.
Implications:
- Highlights the importance of recognizing atypical presentations of Hashimoto's ophthalmopathy.
- Suggests that prompt glucocorticoid therapy can lead to substantial recovery even in unusual cases.
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