Related Experiment Video
Updated: May 31, 2026
Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction
Published on: October 14, 2016
Plasma B-type natriuretic peptide level can predict myocardial tissue perfusion in patients undergoing primary
Suk Min Seo1, Seonghun Kim, Kiyuk Chang
1Division of Cardiovascular Center and Cardiology, Incheon St. Mary's Hospital, Korea.
Insights
High B-type natriuretic peptide (BNP) levels in ST-segment elevation myocardial infarction (STEMI) patients indicate poor myocardial tissue perfusion after primary percutaneous coronary intervention (PCI). Admission BNP levels can predict perfusion status post-PCI.
Area of Science:
- Cardiology
- Biomarkers
- Myocardial Infarction
Background:
- Inadequate myocardial tissue perfusion post-revascularization in STEMI correlates with adverse outcomes.
- Predicting perfusion status is crucial for managing STEMI patients.
Purpose of the Study:
- To investigate if plasma B-type natriuretic peptide (BNP) levels on admission predict myocardial tissue perfusion after primary PCI in STEMI patients.
Main Methods:
- 102 STEMI patients undergoing primary PCI within 12 hours of symptom onset were prospectively enrolled.
- Myocardial tissue perfusion was assessed using ST-segment resolution, corrected thrombolysis in myocardial infarction frame count, and myocardial blush grade.
- All-cause mortality at 1 month was evaluated.
Main Results:
- Patients with high BNP (≥80 pg/ml) showed significantly lower ST-segment resolution, higher corrected thrombolysis in myocardial infarction frame count, and lower myocardial blush grade compared to low-BNP (<80 pg/ml) group.
- High-BNP group exhibited higher short-term mortality (16.2% vs. 3.3%).
- Low-BNP was an independent predictor of good myocardial tissue perfusion (OR 4.12, P<0.01).
Conclusions:
- Higher admission BNP levels in STEMI patients are associated with inadequate myocardial tissue perfusion after primary PCI.
- Plasma BNP levels on admission may serve as a valuable predictor of tissue perfusion post-primary PCI in STEMI.
Background:
Inadequate myocardial tissue perfusion after successful revascularization in ST-segment elevation myocardial infarction (STEMI) is associated with worse clinical outcomes. We investigated whether the plasma B-type natriuretic peptide (BNP) level on admission could predict the status of myocardial tissue perfusion in patients who underwent primary percutaneous coronary intervention (PCI).
Methods:
The study prospectively enrolled 102 patients with STEMI who underwent primary PCI within 12 h of symptom onset. The grade of myocardial tissue perfusion was measured by ST-segment resolution, corrected thrombolysis in myocardial infarction frame count, and myocardial blush grade after primary PCI. All-cause mortality at 1 month after PCI was assessed.
Results:
All patients were divided into two groups according to the BNP level; high-BNP group (≥80 pg/ml, n=43) and low-BNP group (<80 pg/ml, n=59). High-BNP group had significantly lower ST-segment resolution (42.69 ± 24.85 vs. 71.15 ± 19.37%, P<0.001), higher corrected thrombolysis in myocardial infarction frame count (53.7 ± 19.7 vs. 44.5 ± 15.5, P=0.04), lower myocardial blush grade (2.4 ± 0.9 vs. 2.9 ± 0.3, P=0.001), and higher short-term mortality (16.2 vs. 3.3%, P=0.023). In multivariate logistic regression analysis for prediction of good myocardial tissue perfusion after PCI, the odds ratio of low-BNP group was 4.12 (95% confidence interval 1.49-13.08, P<0.01).
Conclusion:
The patients with STEMI who had higher BNP level on admission showed inadequate myocardial tissue perfusion status after primary PCI. The plasma BNP level on admission may serve as a predictor of tissue perfusion after primary PCI in patients with STEMI.
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:30Acute Coronary Syndrome I: Introduction