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Celiac disease in children with diarrhea in 4 cities in China

Xin-qiong Wang1, Wei Liu, Chun-di Xu

  • 1Department of Pediatrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Journal of Pediatric Gastroenterology and Nutrition
|June 25, 2011
PubMed

Insights

Celiac disease (CD) was investigated as a cause of chronic diarrhea in Chinese pediatric patients. This study identified the first reported cases of CD in this population, indicating its potential role.

Area of Science:

  • Gastroenterology
  • Pediatric Medicine
  • Immunology

Background:

  • Chronic diarrhea is a common pediatric concern.
  • Celiac disease (CD) is an autoimmune disorder triggered by gluten.
  • The prevalence of CD in China, particularly in relation to chronic diarrhea, is not well-established.

Purpose of the Study:

  • To determine if celiac disease (CD) is a significant cause of chronic diarrhea in Chinese children.
  • To report the initial findings of CD in Chinese patients presenting with chronic diarrhea.

Main Methods:

  • A prospective study was conducted from January 2005 to December 2008.
  • Patients with chronic diarrhea were recruited from pediatric hospitals in four major Chinese cities.
  • Clinical history, physical examinations, and laboratory data were systematically collected and analyzed.

Main Results:

  • Out of 199 patients with chronic diarrhea, 118 were enrolled.
  • A diagnosis of celiac disease (CD) was confirmed in 14 of the enrolled patients.
  • This represents an 11.9% prevalence of CD among the studied cohort.

Conclusions:

  • The 14 diagnosed patients represent the first documented cases of celiac disease (CD) in Chinese children experiencing chronic diarrhea.
  • These findings suggest that celiac disease should be considered in the differential diagnosis of chronic diarrhea in the Chinese pediatric population.
Abstract

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