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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
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Menses Phase01:18

Menses Phase

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Histology of the Uterus

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Disorders of the Female Reproductive System

The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
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Irritable Bowel Syndrome

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Urinary Tract Infection II: Pathophysiology

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Related Experiment Video

Updated: May 31, 2026

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
07:20

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity

Published on: December 21, 2012

Pathologic basis for abnormal uterine bleeding with organic uterine pathologies.

Debra S Heller1

  • 1Department of Pathology, UH/E158, UMDNJ-New Jersey Medical School, 185 South Orange Ave., Newark, NJ 07103, USA. hellerds@umdnj.edu

Menopause (New York, N.Y.)
|June 25, 2011
PubMed
Summary

Understanding abnormal uterine bleeding mechanisms, particularly from organic causes, is crucial for developing targeted therapies. This review explores the pathological pathways involved in uterine lesions causing bleeding.

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Last Updated: May 31, 2026

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
07:20

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity

Published on: December 21, 2012

Area of Science:

  • Gynecology
  • Pathophysiology
  • Vascular Biology

Background:

  • Abnormal uterine bleeding (AUB) is a common gynecological issue.
  • Organic etiologies of AUB involve intrinsic uterine lesions.
  • Current research often focuses on angiogenesis abnormalities in AUB.

Purpose of the Study:

  • To review the pathological mechanisms of bleeding in organic AUB.
  • To synthesize current literature on the underlying causes of AUB from uterine lesions.
  • To provide a foundation for developing targeted therapeutic strategies.

Main Methods:

  • Literature review of pathological mechanisms in AUB.
  • Analysis of studies focusing on intrinsic uterine lesions and bleeding.
  • Synthesis of research on angiogenesis and other factors in organic AUB.

Main Results:

  • Pathological mechanisms in organic AUB are complex and multifactorial.
  • Angiogenesis plays a significant role, but other factors are also implicated.
  • Understanding these mechanisms is key to identifying therapeutic targets.

Conclusions:

  • Elucidating pathological mechanisms of organic AUB is essential for advancing treatment.
  • Further research into the interplay of vascular and cellular factors is warranted.
  • This review highlights the need for a comprehensive understanding of AUB etiologies.