Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

Neuroplasticity

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Youth Soccer Participation and Brain Health Outcomes in Adolescent Athletes.

JAMA network open·2026

Same author

Brain regional susceptibility to tauopathy in individuals at risk for chronic traumatic encephalopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Same author

Dose-dependent white matter changes associated with repetitive head impacts in former American football players.

Brain communications·2026

Same author

Cognitive, biomarker, and neuroimaging indices associated with traumatic encephalopathy syndrome across two independent athlete cohorts.

Alzheimer's research & therapy·2026

Same author

Cross-population white matter atlas creation for concurrent mapping of brain connections in neonates and adults with diffusion MRI tractography.

Fundamental research·2026

Same author

Premorbid adjustment problems, negative symptoms, and cognitive impairment in a large international sample at clinical high risk for psychosis: Findings from the Accelerating Medicines Partnership-Schizophrenia.

Schizophrenia bulletin·2026

Search research articles

Related Experiment Video

Updated: May 31, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Diffusion MRI of structural brain plasticity induced by a learning and memory task.

Tamar Blumenfeld-Katzir¹, Ofer Pasternak, Michael Dagan

¹Department of Neurobiology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.

|June 25, 2011

Summary

This summary is machine-generated.

Diffusion tensor imaging (DTI) reveals age-dependent and independent neuroplasticity in specific brain regions of rats. This technique helps visualize microstructural changes related to learning and memory, potentially localizing long-term potentiation (LTP).

More Related Videos

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Related Experiment Videos

Last Updated: May 31, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Area of Science:

Neuroscience
Neuroimaging
Structural Plasticity

Background:

Activity-induced structural remodeling of dendritic spines and glial cells is linked to neuroplasticity and long-term potentiation (LTP).
Previous studies used T1 and diffusion MRI for structural changes in long-term training, but cellular basis and neuroplasticity links remain unclear.

Purpose of the Study:

To investigate microstructural manifestations of neuroplasticity using diffusion tensor imaging (DTI).
To explore the cellular basis of MRI findings in neuroplasticity and their relation to LTP.

Main Methods:

Diffusion tensor imaging (DTI) was employed in rats performing a spatial navigation task.
Analysis focused on microstructural changes indicative of neuroplasticity.

Main Results:

DTI successfully defined the selective localization of neuroplasticity induced by different tasks.
Neuroplasticity showed age-dependency in the cingulate cortex and corpus callosum, but was age-independent in the dentate gyrus.

Conclusions:

Observed DTI changes correlate with structural plasticity in astrocytes.
MRI shows potential for probing structural neuroplasticity and indirectly localizing LTP.