[The effect of cholino- and adrenoblockers on limbic-sympathetic evoked potentials]

Effects of i.v. administration of cholino- and adrenergic blocking agents on limbic-sympathetic discharges of L2-L3 white rami, evoked by stimulation of the anterior, visceral area of the limbic cortex and on arterial blood pressure were studied in anesthetized cats. M- and N-cholinoreceptor blocking agents atropine and ganglerone do not induce any apparent changes in limbic-sympathetic discharge and the blood pressure level. Beta-adrenoreceptor blocking agent propranolol evoked a small fall of the blood pressure with no apparent changes of limbic-sympathetic discharges. Alpha-adrenoreceptor blocking agent phenotolamine evoked obvious drop of the blood pressure and, in two out of eight experiments, a marked increase of the amplitude of limbic-sympathetic evoked discharges. Neurochemical regulatory mechanism of limbic-spinal sympathetic activity are discussed.