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Stem cell therapies for type 1 diabetes mellitus

Júilio C Voltarelli1, Carlos E B Couri, Maria C Rodrigues

  • 1Department of Clinical Medicine, RibeirBo Preto School of Medicine, University of São Paulo, Brazil. jcvoltar@fmrp.usp.br

Indian Journal of Experimental Biology
|June 28, 2011
PubMed

The present review discusses the use of autologous hematopoietic stem cell transplantation (HSCT) for the treatment of diabetes mellitus type 1 (DM 1). It has been observed that high dose immunosuppression followed by HSCT shows better results among other immunotherapeutic treatments for the disease as the patients with adequate beta cell reserve achieve insulin independence. However, this response is not maintained and reoccurrence of the disease is major a major challenge to use HSCT in future to prevent or control relapse of DM 1.

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