Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Healing II: Complications

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

Healing I: Introduction

Healing I: Introduction

Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

Overview of Regeneration and Repair

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...

Phases of Wound Repair

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the exudate's...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Novel candidate genes for vestibular function identified through GWAS in the hybrid mouse diversity panel.

BMC genomics·2026

Same author

Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.

Science (New York, N.Y.)·2024

Same author

The genomic landscape of Ménière's disease: a path to endolymphatic hydrops.

BMC genomics·2024

Same author

Genome-Wide Association Study of Chronic Dizziness in the Elderly Identifies Loci Implicating MLLT10, BPTF, LINC01224, and ROS1.

Journal of the Association for Research in Otolaryngology : JARO·2023

Same author

Diversity and Scale: Genetic Architecture of 2,068 Traits in the VA Million Veteran Program.

medRxiv : the preprint server for health sciences·2023

Same author

Marked Increases in Resting-State MEG Gamma-Band Activity in Combat-Related Mild Traumatic Brain Injury.

Cerebral cortex (New York, N.Y. : 1991)·2019

Search research articles

Related Experiment Video

Updated: May 31, 2026

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Published on: April 28, 2022

The nonhealing scar.

Michael Crandall¹, Royce Clifford

¹MAG 39 Medical Department, Box 555750, Building 222190, Camp Pendleton, CA 92055, USA.

Military Medicine

|June 28, 2011

Summary

Pyogenic granulomas, common skin growths, can be challenging to treat in remote settings. This case report details successful management of a pyogenic granuloma in an austere environment, offering treatment options for limited-resource situations.

Area of Science:

Dermatology
Global Health
Trauma Care

Background:

Pyogenic granulomas are frequent, benign vascular skin tumors.
Trauma is a common precursor to pyogenic granuloma formation.
Effective treatment in resource-limited or austere environments presents unique challenges.

Observation:

A case of pyogenic granuloma developed at the site of a previously treated laceration in an austere setting.
The pyogenic granuloma was successfully managed using available resources.

Findings:

This report details the first published case of a pyogenic granuloma in an austere environment.
Multiple treatment modalities, including topical imiquimod, ethanol injection, silver nitrate, and oral steroids, are viable options for managing pyogenic granulomas in resource-constrained settings.

More Related Videos

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

Published on: November 29, 2024

Related Experiment Videos

Last Updated: May 31, 2026

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Published on: April 28, 2022

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

Published on: November 29, 2024

Implications:

This work highlights the feasibility of treating pyogenic granulomas even in austere environments.
It provides a valuable resource for healthcare providers facing similar clinical scenarios with limited access to specialized care.
The findings support the adaptation of existing treatment protocols for pyogenic granulomas to austere medical contexts.