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Related Experiment Video

Updated: May 31, 2026

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Published on: April 13, 2022

Tooth tissue engineering: optimal dental stem cell harvest based on tooth development.

Monica Talarico Duailibi¹, Silvio Eduardo Duailibi, Eduardo Felippe Duailibi Neto

¹Interdisciplinary Center of Gene Therapy, UNIFESP-CINTERGEN, Department of Plastic Surgery, Federal University of São Paulo, Brazil.

Artificial Organs

|June 28, 2011

Summary

A new radiographic staging system helps identify human teeth with the most dental stem cells (DSCs) for tissue engineering. Early developmental stages (1 and 2) yield higher cell numbers and colony-forming units (CFUs) for regenerative dentistry.

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Primary Culture of Dental Pulp Stem Cells

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Last Updated: May 31, 2026

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Published on: April 13, 2022

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

Published on: November 24, 2012

Primary Culture of Dental Pulp Stem Cells

Primary Culture of Dental Pulp Stem Cells

Published on: May 5, 2023

Area of Science:

Regenerative Medicine
Dental Tissue Engineering
Stem Cell Biology

Background:

Tissue engineering aims to create biological replacement teeth with natural properties.
Previous studies successfully generated bioengineered tooth crowns using animal dental stem cells (DSCs).

Purpose of the Study:

To develop a radiographic staging system for human third molars.
To correlate tooth developmental stage with dental stem cell (DSC) yield for tissue engineering.

Main Methods:

A novel radiographic staging system was developed for human third molars.
Dental stem cell (DSC) yield and colony-forming units (CFUs) were quantified based on developmental stage.

Main Results:

Higher DSC yields were observed in less developed teeth (Stages 1 and 2).
Greatest cell yields and CFUs were obtained from the dental pulp of Stages 1 and 2 teeth.
Lower DSC yields were found in more developed teeth (Stages 3-5).

Conclusions:

Radiographic developmental staging accurately predicts the utility of human teeth for dental tissue engineering.
Early developmental stages (1 and 2) are optimal for harvesting DSCs for regenerative applications.