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Related Experiment Video

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Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
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Systemic lupus erythematosus presenting with eosinophilic enteritis: a case report.

Mehrnaz Asadi Gharabaghi1, Pejman Abdollahi, Mohammad Kalany

  • 1Department of General Internal Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. asadi_m@tums.ac.ir.

Journal of Medical Case Reports
|June 28, 2011
PubMed
Summary

Systemic lupus erythematosus (SLE) can cause chronic diarrhea due to eosinophilic enteritis. Early consideration of SLE in patients with diarrhea and lymphopenia aids diagnosis and treatment.

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Published on: November 1, 2015

Area of Science:

  • Gastroenterology
  • Rheumatology
  • Immunology

Background:

  • Systemic lupus erythematosus (SLE) is a complex autoimmune disease with diverse clinical manifestations.
  • Gastrointestinal involvement in SLE includes transaminitis, vasculitis, enteritis, and mesenteric vascular leakage.
  • Eosinophilic enteritis is an uncommon cause of chronic diarrhea in SLE patients.

Purpose of the Study:

  • To report a rare case of SLE presenting initially with chronic diarrhea due to eosinophilic enteritis.
  • To highlight the importance of considering SLE in patients with unexplained chronic diarrhea and lymphopenia.

Main Methods:

  • Case report of a 38-year-old woman with a five-month history of diarrhea and abdominal pain.
  • Initial investigations revealed lymphopenia and mild eosinophilia without a clear autoimmune or infectious cause.
  • Diagnosis was confirmed after the development of lupus-like skin lesions and small bowel wall thickening on CT scan, revealing eosinophilic enteritis as the cause of diarrhea.

Main Results:

  • The patient presented with chronic diarrhea and abdominal pain, initially attributed to lymphopenia and eosinophilia.
  • Development of a characteristic scalp lesion led to further investigation.
  • Computed tomography revealed small bowel wall thickening, ultimately diagnosing eosinophilic enteritis as the cause of her symptoms, indicative of Systemic Lupus Erythematosus.

Conclusions:

  • Considering Systemic Lupus Erythematosus in patients presenting with chronic diarrhea and lymphopenia is crucial for timely diagnosis.
  • This case underscores the varied gastrointestinal presentations of SLE.
  • Early diagnosis and treatment of SLE-associated eosinophilic enteritis can improve patient outcomes.