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Updated: May 31, 2026

Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis
Published on: November 17, 2011
Functional lipidomics of oxidized products from polyunsaturated fatty acids
1Université de Lyon, UMR 1060/CarMeN, INSERM, IMBL, INSA-Lyon, Univ-Lyon 1, INRA, Villeurbanne, France.
Abstract:
Because of their high degree of unsaturation, polyunsaturated fatty acids (PUFA) in mammals, with mainly 18, 20 and 22 carbons, can easily be autooxidized, and converted into many oxidized derivatives and degradation products. This short review reports on some of those relevant to the evaluation of oxidative stress in situ. In addition, the enzyme-dependent oxygenation by both dioxygenases and monooxygenases is briefly reviewed by functional and/or metabolic categories, pointing out the structure variety and the analytical approaches.
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