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Related Experiment Video

Updated: May 31, 2026

A Gaze-Contingent Display Framework for Perceptual Learning Research with Simulated Central Vision Loss

A Gaze-Contingent Display Framework for Perceptual Learning Research with Simulated Central Vision Loss

Published on: April 11, 2025

Disrupted functional connectivity for controlled visual processing as a basis for impaired spatial working memory in

Seung Suk Kang¹, Scott R Sponheim, Matthew V Chafee

¹Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA.

Neuropsychologia

|June 28, 2011

Summary

Schizophrenia patients show disrupted brain connectivity in spatial working memory (SWM) networks. Functional disconnection between prefrontal and posterior visual areas underlies SWM deficits in schizophrenia.

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Modeling the Functional Network for Spatial Navigation in the Human Brain

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

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Last Updated: May 31, 2026

A Gaze-Contingent Display Framework for Perceptual Learning Research with Simulated Central Vision Loss

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Published on: April 11, 2025

Modeling the Functional Network for Spatial Navigation in the Human Brain

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

Area of Science:

Neuroscience
Cognitive Neuroscience
Psychiatry

Background:

Schizophrenia is associated with spatial working memory (SWM) deficits.
Previous research identified regional brain abnormalities but lacked insight into functional network disruptions within the SWM network in schizophrenia.

Purpose of the Study:

To investigate SWM-related interregional functional connectivity in schizophrenia.
To identify specific brain circuits functionally disrupted in the SWM network.

Main Methods:

Functional magnetic resonance imaging (fMRI) data from 12 schizophrenia patients and 11 healthy controls.
Analysis of brain activation covariation during a spatial information processing task under low and high SWM load conditions.

Main Results:

Schizophrenia patients exhibited SWM performance deficits and reduced neural activation, particularly under high SWM load.
Evidence of functional disconnection between prefrontal and posterior visual association areas in schizophrenia.
Reduced functional associations were found between dorsolateral prefrontal cortex (DLPFC) and inferior temporal cortex (ITC) in the right hemisphere under low SWM load.
Under high SWM load, further disconnection was observed, including between left DLPFC and right visual areas (posterior parietal cortex (PPC), fusiform gyrus, V1), and right inferior frontal cortex and right PPC.
In controls, greater prefrontal-posterior cortical functional connectivity correlated with better SWM performance, but this association was absent in patients.

Conclusions:

Prefrontal-posterior functional connectivity is crucial for the maintenance and control of visual information in SWM.
Disruption of this functional network significantly contributes to SWM deficits observed in schizophrenia.