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Updated: May 31, 2026

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique
Published on: September 10, 2014
Biological basis of exercise-based treatments for musculoskeletal conditions
Fabrisia Ambrosio1, Ayman Tarabishy, Fawzi Kadi
1Department of Physical Medicine and Rehabilitation, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA. ambrosiof@upmc.edu
Abstract:
Exercise-based therapies are the cornerstone of rehabilitation programs. While the benefits of exercise on systemic and tissue function are generally accepted, mechanisms underlying these benefits are sometimes poorly understood. An improved understanding of the effects of mechanical loading on molecular and cellular processes has the potential to lead to more disease-specific and efficacious exercise-based therapies. The purpose of this paper is to review the current literature examining the role of mechanical signaling on muscle and cartilage biology.
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