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Updated: May 31, 2026

Surgical Techniques to Optimize Ovarian Reserve during Laparoscopic Cystectomy for Ovarian Endometrioma
Published on: January 22, 2022
Follicular loss in endoscopic surgery for ovarian endometriosis: quantitative and qualitative observations
Daniela Romualdi1, Gian Franco Zannoni, Antonio Lanzone
1Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy.
Objective:
To identify a possible marker of follicular depletion in relation to some histologic parameters of endometriotic cysts.
Design:
Prospective study.
Setting:
Università Cattolica del Sacro Cuore, Operative Division of Endocrinological Gynecology.
Patient(S):
Seventy-seven patients (aged 20-40 years) with endometrioma.
Intervention(S):
Patients underwent laparoscopic surgery for ovarian endometriosis.
Main Outcome Measure(S):
After excision of the cyst wall, involuntarily removed follicles were correlated with age at surgery and with intrinsic histologic parameters of the specimen (thickness and composition of capsule; size of cyst).
Result(S):
There was a statistically significant relationship between patient age and number of follicles in the histologic section, a statistically significant inverse relationship between size of cyst and number of follicles, and no significant correlation between thickness of the capsule and number of follicles. Fibroblastic-type capsule, most frequently found in younger patients, was associated with removal of a significantly higher number of follicles.
Conclusion(S):
Our study suggests that patient age and cyst dimension are related to the histologic composition of the capsule, which is a marker of the aggressiveness of the cyst itself.
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