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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...

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Related Experiment Videos

Ischemic stroke in patients receiving aspirin.

Virginia A Pujol Lereis1, Sebastian Ameriso, Guillermo P Povedano

  • 1Institute for Neurological Research, FLENI, Buenos Aires, Argentina.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|June 28, 2011
PubMed
Summary

Aspirin failure in stroke prevention is common, even in patients without aspirin resistance. Risk factors like hypertension and comorbidities may contribute, suggesting a need for alternative strategies.

Related Experiment Videos

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Aspirin is widely used for vascular prevention, yet first and recurrent ischemic strokes still occur.
  • Factors beyond aspirin resistance contribute to aspirin failure.
  • Current guidelines lack clear strategies for stroke patients on aspirin.

Purpose of the Study:

  • To assess clinical features of patients experiencing ischemic stroke while taking aspirin.
  • To identify factors associated with aspirin failure in stroke prevention.

Main Methods:

  • Retrospective analysis of 709 patients with first or recurrent ischemic strokes.
  • Evaluation of demographic characteristics, vascular risk factors, stroke subtypes, and medications.
  • Exclusion of patients on non-aspirin antiplatelets or oral anticoagulants.

Main Results:

  • Aspirin use was noted in 29% of first and 48% of recurrent stroke patients.
  • Aspirin users showed higher rates of hypertension, hypercholesterolemia, and smoking.
  • Comorbidities like diabetes and coronary artery disease were more prevalent in first-stroke aspirin users.

Conclusions:

  • Aspirin failure in ischemic stroke may be linked to lacunar stroke, comorbidities, and drug interactions.
  • These findings suggest a need for personalized prevention strategies beyond aspirin.
  • Alternative approaches are warranted for patients experiencing stroke despite aspirin therapy.