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Ischemic stroke in patients receiving aspirin

Virginia A Pujol Lereis1, Sebastian Ameriso, Guillermo P Povedano

  • 1Institute for Neurological Research, FLENI, Buenos Aires, Argentina.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|June 28, 2011
PubMed

Insights

Aspirin failure in stroke prevention is common, even in patients without aspirin resistance. Risk factors like hypertension and comorbidities may contribute, suggesting a need for alternative strategies.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Aspirin is widely used for vascular prevention, yet first and recurrent ischemic strokes still occur.
  • Factors beyond aspirin resistance contribute to aspirin failure.
  • Current guidelines lack clear strategies for stroke patients on aspirin.

Purpose of the Study:

  • To assess clinical features of patients experiencing ischemic stroke while taking aspirin.
  • To identify factors associated with aspirin failure in stroke prevention.

Main Methods:

  • Retrospective analysis of 709 patients with first or recurrent ischemic strokes.
  • Evaluation of demographic characteristics, vascular risk factors, stroke subtypes, and medications.
  • Exclusion of patients on non-aspirin antiplatelets or oral anticoagulants.

Main Results:

  • Aspirin use was noted in 29% of first and 48% of recurrent stroke patients.
  • Aspirin users showed higher rates of hypertension, hypercholesterolemia, and smoking.
  • Comorbidities like diabetes and coronary artery disease were more prevalent in first-stroke aspirin users.

Conclusions:

  • Aspirin failure in ischemic stroke may be linked to lacunar stroke, comorbidities, and drug interactions.
  • These findings suggest a need for personalized prevention strategies beyond aspirin.
  • Alternative approaches are warranted for patients experiencing stroke despite aspirin therapy.
Abstract

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