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Updated: May 31, 2026

Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice
06:48

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Complement regulates CD4 T-cell help to CD8 T cells required for murine allograft rejection

Mark Vieyra1, Staci Leisman, Hugo Raedler

  • 1Renal Division, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.

The American Journal of Pathology
|June 28, 2011
PubMed
Summary

CD4 T-cell help for CD8 T-cell responses to transplants is transmitted via complement fragments C3a and C5a. These molecules act as bridges, linking CD4 help to CD8 T cells and influencing transplant rejection.

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