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Updated: May 31, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
From benzodiazepines to peripheral and brain steroid biosynthesis
1The Research Institute of the McGill University Health Centre and the Department of Medicine, McGill University, Montreal General Hospital, 1650 Cedar Avenue, C10-148, Montreal, Quebec H3G 1A4, Canada. vassilios.papadopoulos@mcgill.ca
This review highlights the catalytic role of Erminio Costa in advancing our understanding of neurosteroid biosynthesis and its connection to benzodiazepines. It showcases the development of neurosteroidogenesis pharmacology.
Area of Science:
- Neuroscience
- Pharmacology
- Biochemistry
Background:
- Explores the biochemistry of testicular and adrenal steroids.
- Investigates the biosynthesis of steroids in the brain.
Observation:
- Details two career transitions from steroid biochemistry to neuropharmacology.
- Highlights the catalytic role of Erminio (Mimo) Costa in these transitions.
Findings:
- Reviews findings on the link between benzodiazepines and neurosteroid biosynthesis.
- Establishes the pharmacology of neurosteroidogenesis.
Implications:
- Demonstrates Dr. Costa's influence in challenging existing scientific notions.
- Inspires further research into neurosteroidogenesis and its pharmacological applications.
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