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Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

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Published on: August 4, 2019

TP53 mutations in human cancer: database reassessment and prospects for the next decade

Thierry Soussi1

  • 1Department of Oncology-Pathology, Cancer Center Karolinska (CCK), Karolinska Institute, Stockholm, Sweden.

Advances in Cancer Research
|June 28, 2011
PubMed

Insights

TP53 mutation databases track over 30,000 cancer mutations, aiding research. Future advancements will significantly impact TP53 database curation and data management strategies.

Area of Science:

  • Oncology
  • Genetics
  • Bioinformatics

Background:

  • TP53 mutations are the most common genetic alterations in human cancers.
  • TP53 mutation databases have accumulated over 30,000 somatic mutations from diverse cancer types.
  • Extensive analysis of these mutations has enhanced understanding of the TP53 protein and its functions.

Purpose of the Study:

  • To review the current state of the TP53 mutation database.
  • To discuss the applications of TP53 mutation data in various research fields.
  • To explore improvements in data quality and curation for TP53 databases.

Main Methods:

  • Review of existing TP53 mutation databases.
  • Analysis of the impact of recent sequencing technologies and cancer genome projects.
  • Discussion of future data storage, handling, and management strategies.

Main Results:

  • TP53 mutation databases are valuable resources for cancer research.
  • Advances in sequencing necessitate updates in database curation and management.
  • Improved data quality and curation are crucial for future research.

Conclusions:

  • The TP53 mutation database is a critical resource in cancer genetics.
  • Future database management must adapt to new sequencing technologies and large-scale data.
  • Enhanced data quality and curation will maximize the utility of TP53 mutation data for advancing cancer research.

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