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Related Concept Videos

Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...

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Related Experiment Video

Updated: May 31, 2026

Cell Type-specific Gene Expression Profiling in the Mouse Liver
10:06

Cell Type-specific Gene Expression Profiling in the Mouse Liver

Published on: September 17, 2019

Novel biological insights revealed from cell type-specific expression profiling.

Mallorie Taylor-Teeples1, Mily Ron, Siobhan M Brady

  • 1Department of Plant Biology and Genome Center, University of California, Davis, Davis, CA 95616, USA.

Current Opinion in Plant Biology
|June 28, 2011
PubMed
Summary
This summary is machine-generated.

Cell-specific expression profiling reveals novel insights into plant development and stress responses. This approach uncovers epigenetic mechanisms and genetic pathways essential for cell identity, surpassing traditional genetic methods.

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Last Updated: May 31, 2026

Cell Type-specific Gene Expression Profiling in the Mouse Liver
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TChIP-Seq: Cell-Type-Specific Epigenome Profiling
07:28

TChIP-Seq: Cell-Type-Specific Epigenome Profiling

Published on: January 23, 2019

Area of Science:

  • Plant molecular biology
  • Genomics
  • Developmental biology

Background:

  • Transcriptional regulation is crucial for establishing and maintaining cell identity.
  • Cell type-resolution expression profiling generates valuable datasets for biological discovery.
  • Existing expression maps offer tools for identifying novel cell types and pathways.

Purpose of the Study:

  • To highlight the utility of cell type-specific expression profiling in uncovering biological insights.
  • To demonstrate the application of expression maps in defining novel cell types and pathways.
  • To showcase how this approach identifies genes and pathways involved in development and stress response.

Main Methods:

  • Analysis of cell type-resolution expression profiling datasets.
  • Utilizing recently developed expression maps of plant tissues (e.g., shoot apical meristem, gametophytes).
  • Comparative analysis with traditional genetics.

Main Results:

  • Expression maps have revealed cell type-specific epigenetic regulatory mechanisms crucial for development.
  • This profiling approach identified genes and pathways involved in development that are difficult to find with traditional genetics.
  • Novel cell types and regulatory pathways can be defined using these expression maps.

Conclusions:

  • Cell type-specific expression profiling is a powerful tool for advancing biological understanding.
  • Expression maps significantly enhance the discovery of developmental and stress-response genes and pathways.
  • This methodology provides a more comprehensive approach than traditional genetics for uncovering complex biological processes.