Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
Bioplastics01:27

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
Plasticizers01:31

Plasticizers

Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Responses to Heat and Cold Stress02:45

Responses to Heat and Cold Stress

Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regularized micromagnetic theory for Bloch points.

Communications physics·2026
Same author

Insights from an invited expert panel using a World Café: Establishing a national human biomonitoring programme communication strategy.

Environment international·2026
Same author

Insights from an invited expert panel using a World Café: Developing a national policy for a human biomonitoring programme.

Environment international·2026
Same author

Spin-Disorder-Induced Angular Anisotropy in Polarized Magnetic Neutron Scattering.

Physical review letters·2025
Same author

Chemical Prioritisation for Human Biomonitoring in Ireland: A Synergy of Global Frameworks and Local Perspectives.

Toxics·2025
Same author

Quantum Magnetic Skyrmion Operator.

Physical review letters·2024

Related Experiment Video

Updated: May 31, 2026

Collection of Alfalfa Root Exudates to Study the Impact of Di(2-ethylhexyl) Phthalate on Metabolite Production
06:46

Collection of Alfalfa Root Exudates to Study the Impact of Di(2-ethylhexyl) Phthalate on Metabolite Production

Published on: June 2, 2023

Phthalate exposure during cold plastisol application--a human biomonitoring study.

Holger Martin Koch1, Andreas Haller, Tobias Weiss

  • 1Institute for Prevention and Occupational Medicine of German Social Accident Insurance - Institute of the Ruhr-Universität Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany. koch@ipa-dguv.de

Toxicology Letters
|June 28, 2011
PubMed
Summary

Occupational exposure to DiNP and DiDP phthalates in plastisol workers significantly elevates metabolite levels, indicating higher workplace exposure compared to the general population. Dermal absorption may be a key factor in this exposure.

More Related Videos

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor
09:33

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

Published on: March 21, 2018

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

Related Experiment Videos

Last Updated: May 31, 2026

Collection of Alfalfa Root Exudates to Study the Impact of Di(2-ethylhexyl) Phthalate on Metabolite Production
06:46

Collection of Alfalfa Root Exudates to Study the Impact of Di(2-ethylhexyl) Phthalate on Metabolite Production

Published on: June 2, 2023

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor
09:33

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

Published on: March 21, 2018

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

Area of Science:

  • Occupational Health
  • Environmental Chemistry
  • Toxicology

Background:

  • Phthalates like DEHP, DiNP, and DiDP are common in plastisols.
  • Occupational exposure data for these phthalates in plastisol use is limited.

Purpose of the Study:

  • To assess occupational exposure to DEHP, DiNP, and DiDP in workers using plastisol.
  • To quantify phthalate metabolite levels in urine to determine exposure levels.

Main Methods:

  • Urine samples (pre- and post-shift) were collected from 5 plastisol workers and 10 controls.
  • Phthalate metabolites (DiNP, DiDP) were analyzed.
  • Comparison of metabolite levels between exposed workers and a general population reference group.

Main Results:

  • Plastisol workers showed significantly higher pre- and post-shift urinary metabolite levels for DiNP and DiDP (5-20 times higher than controls).
  • DiDP metabolite levels were generally lower than DiNP.
  • No significant work-related exposure to DEHP was detected.

Conclusions:

  • Workers using DiNP-based plastisol exhibit elevated occupational exposure to DiNP and DiDP.
  • Dermal exposure is a potential significant route for phthalates in plastisols.
  • Further research is needed to understand phthalate kinetics and interpretation of exposure data.