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Related Experiment Video

Updated: May 31, 2026

A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva

A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva

Published on: July 5, 2017

Ocular symptoms in nonspecific conjunctival hyperreactivity.

Elizabeth Maria Mercer Mourão¹, Nelson Augusto Rosário, Luciano Silva

¹Postgraduate, Department of Internal Medicine, Federal University of Paraná, Curitiba, Brazil. emourao@terra.com.br

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology

|June 28, 2011

Summary

The hyperosmolar conjunctival provocation test (HCPT) effectively identifies conjunctival hyperreactivity (CHR) in allergic and non-allergic individuals. This test is valuable for assessing ocular symptoms, even in asymptomatic allergic subjects.

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Area of Science:

Ophthalmology
Allergy and Immunology
Clinical Research

Background:

Nonspecific environmental factors can trigger ocular symptoms, a condition known as conjunctival hyperreactivity (CHR).
CHR is characterized by an exaggerated ocular response to various stimuli.

Purpose of the Study:

To evaluate the utility of the hyperosmolar conjunctival provocation test (HCPT) in identifying CHR.
To assess CHR in individuals presenting with ocular symptoms like itching, redness, or tearing.

Main Methods:

Sixty-three subjects with ocular complaints underwent allergy testing for common inhalant allergens.
The HCPT involved applying serial glucose concentrations to the conjunctiva, with positive results indicated by conjunctival hyperemia up to a 50% glucose solution.
Digital images of ocular redness were objectively analyzed to quantify hyperemia.

Main Results:

The HCPT demonstrated high sensitivity (87%) and specificity (84%) in identifying allergic subjects.
CHR was detected in 87% of allergic subjects and 16% of non-allergic subjects.
A strong correlation (r = 0.96) was observed between observer-marked digital images and hyperemia quantification.

Conclusions:

The HCPT is a reliable method for identifying conjunctival hyperreactivity (CHR) in both allergic and non-allergic individuals.
Allergic subjects exhibited significantly higher levels of CHR compared to non-allergic subjects.
CHR can be present in allergic individuals even in the absence of overt symptoms, and digital imaging aids in objective assessment.