Relationship between cAMP concentration in anterior hypothalamic-preoptic region and the ultradian wake-sleep cycle

In the rat anterior hypothalamic-preoptic region adenosine 3':5'-cyclic monophosphate concentration changes during the ultradian wake-sleep cycle. The administration of DL-propranolol and the exposure to low ambient temperature decreased the nucleotide concentration and also modified the wake-sleep cycle. This suggests that in this region a biochemical correlation exists with different functional states.