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Related Experiment Video

Updated: May 31, 2026

Live-cell Imaging of Single-Cell Arrays (LISCA) - a Versatile Technique to Quantify Cellular Kinetics

Live-cell Imaging of Single-Cell Arrays (LISCA) - a Versatile Technique to Quantify Cellular Kinetics

Published on: March 18, 2021

TimeLapseAnalyzer: multi-target analysis for live-cell imaging and time-lapse microscopy.

Johannes Huth¹, Malte Buchholz, Johann M Kraus

¹Department of Gastroenterology and Endocrinology, University Hospital of Marburg, Germany.

Computer Methods and Programs in Biomedicine

|June 28, 2011

Summary

TimeLapseAnalyzer offers automated, reproducible analysis of live-cell imaging data. This open-source software enhances high-throughput screening by analyzing cell motility, proliferation, and more.

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Area of Science:

Cell biology
Microscopy
Image analysis

Background:

Live-cell imaging generates vast data, necessitating automated analysis.
Accurate cell behavior analysis is crucial for biomarker discovery and diagnostics.

Purpose of the Study:

To develop an automated, extensible software package for analyzing live-cell time-lapse microscopy data.
To provide fast and reproducible analysis of multiple cell behavior aspects.

Main Methods:

Developed TimeLapseAnalyzer, a modular, cross-platform package.
Integrated image enhancement, segmentation, and specialized analysis modules.
Enabled analysis of cell tracking, scratch wound healing, cell counting, and tube formation.

Main Results:

TimeLapseAnalyzer provides fast and reliable analysis of diverse cell behaviors.
The software supports high-throughput screening of live-cell experiments.
It offers general image processing and specific biological assays.

Conclusions:

TimeLapseAnalyzer is a valuable, freely available tool for live-cell imaging analysis.
The software facilitates reproducible research and biomarker discovery.
Its modular design allows for extensibility and broad application.