Related Experiment Video
Updated: May 31, 2026
Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
HLA-B27 association with uveitis in an Asian Indian population
Mahendra Narin Mishra1, Khurshed Minoo Bharucha
1Dr. Lal Pathology Reference Laboratory, Rohini, New Delhi, India. mnmishra@hotmail.com
Background:
Uveitis refers to diseases characterized by intraocular inflammation of the uveal tract. Anterior uveitis is a common ocular disease characterized by inflammation of the iris and the ciliary body.
Objectives:
To establish the frequency of HLA-B27-positive uveitis in Asian Indian population, study their clinical profile and compare it with other reports in literature.
Methods:
We retrospectively reviewed medical data of 89 patients of uveitis referred for HLA B27 typing with predominantly ocular symptoms during the period from April 2006-October 2010. All patients were tested for complete blood count, erythrocyte sedimentation rate, infectious diseases serology, HLA-B27 typing, and prepared radiographs of the sacroiliac joints and lumbar spine if required.
Results:
The HLA-B27 positive rate was 56.2% among patients and 3% for control samples. Most of the patients were in the age group of 41-50 years with a male predominance.
Conclusions:
HLA-B27 was seen to be associated with acute anterior uveitis in Asian Indian males and the test is important for confirmation of diagnosis, prognostication and also for planning the treatment.
